Reuniting philosophy and science to advance cancer research

Research output: Contribution to journal › Journal article › Research › peer-review

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Reuniting philosophy and science to advance cancer research. / Pradeu, Thomas; Daignan-Fornier, Bertrand; Ewald, Andrew; Germain, Pierre Luc; Okasha, Samir; Plutynski, Anya; Benzekry, Sébastien; Bertolaso, Marta; Bissell, Mina; Brown, Joel S.; Chin-Yee, Benjamin; Chin-Yee, Ian; Clevers, Hans; Cognet, Laurent; Darrason, Marie; Farge, Emmanuel; Feunteun, Jean; Galon, Jérôme; Giroux, Elodie; Green, Sara; Gross, Fridolin; Jaulin, Fanny; Knight, Rob; Laconi, Ezio; Larmonier, Nicolas; Maley, Carlo; Mantovani, Alberto; Moreau, Violaine; Nassoy, Pierre; Rondeau, Elena; Santamaria, David; Sawai, Catherine M.; Seluanov, Andrei; Sepich-Poore, Gregory D.; Sisirak, Vanja; Solary, Eric; Yvonnet, Sarah; Laplane, Lucie.

In: Biological Reviews, Vol. 98, 2023, p. 1668-1686.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pradeu, T, Daignan-Fornier, B, Ewald, A, Germain, PL, Okasha, S, Plutynski, A, Benzekry, S, Bertolaso, M, Bissell, M, Brown, JS, Chin-Yee, B, Chin-Yee, I, Clevers, H, Cognet, L, Darrason, M, Farge, E, Feunteun, J, Galon, J, Giroux, E, Green, S, Gross, F, Jaulin, F, Knight, R, Laconi, E, Larmonier, N, Maley, C, Mantovani, A, Moreau, V, Nassoy, P, Rondeau, E, Santamaria, D, Sawai, CM, Seluanov, A, Sepich-Poore, GD, Sisirak, V, Solary, E, Yvonnet, S & Laplane, L 2023, 'Reuniting philosophy and science to advance cancer research', Biological Reviews, vol. 98, pp. 1668-1686. https://doi.org/10.1111/brv.12971

APA

Pradeu, T., Daignan-Fornier, B., Ewald, A., Germain, P. L., Okasha, S., Plutynski, A., Benzekry, S., Bertolaso, M., Bissell, M., Brown, J. S., Chin-Yee, B., Chin-Yee, I., Clevers, H., Cognet, L., Darrason, M., Farge, E., Feunteun, J., Galon, J., Giroux, E., ... Laplane, L. (2023). Reuniting philosophy and science to advance cancer research. Biological Reviews, 98, 1668-1686. https://doi.org/10.1111/brv.12971

Vancouver

Pradeu T, Daignan-Fornier B, Ewald A, Germain PL, Okasha S, Plutynski A et al. Reuniting philosophy and science to advance cancer research. Biological Reviews. 2023;98:1668-1686. https://doi.org/10.1111/brv.12971

Author

Pradeu, Thomas ; Daignan-Fornier, Bertrand ; Ewald, Andrew ; Germain, Pierre Luc ; Okasha, Samir ; Plutynski, Anya ; Benzekry, Sébastien ; Bertolaso, Marta ; Bissell, Mina ; Brown, Joel S. ; Chin-Yee, Benjamin ; Chin-Yee, Ian ; Clevers, Hans ; Cognet, Laurent ; Darrason, Marie ; Farge, Emmanuel ; Feunteun, Jean ; Galon, Jérôme ; Giroux, Elodie ; Green, Sara ; Gross, Fridolin ; Jaulin, Fanny ; Knight, Rob ; Laconi, Ezio ; Larmonier, Nicolas ; Maley, Carlo ; Mantovani, Alberto ; Moreau, Violaine ; Nassoy, Pierre ; Rondeau, Elena ; Santamaria, David ; Sawai, Catherine M. ; Seluanov, Andrei ; Sepich-Poore, Gregory D. ; Sisirak, Vanja ; Solary, Eric ; Yvonnet, Sarah ; Laplane, Lucie. / Reuniting philosophy and science to advance cancer research. In: Biological Reviews. 2023 ; Vol. 98. pp. 1668-1686.

Bibtex

@article{a8d07a93c270472c9a24fd7e92445203,

title = "Reuniting philosophy and science to advance cancer research",

abstract = "Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.",

keywords = "cancer stem cells, clonal evolution, driver mutation, multicellularity, oncoimmunology, philosophy of cancer, tumorigenesis, tumour microenvironment",

author = "Thomas Pradeu and Bertrand Daignan-Fornier and Andrew Ewald and Germain, {Pierre Luc} and Samir Okasha and Anya Plutynski and S{\'e}bastien Benzekry and Marta Bertolaso and Mina Bissell and Brown, {Joel S.} and Benjamin Chin-Yee and Ian Chin-Yee and Hans Clevers and Laurent Cognet and Marie Darrason and Emmanuel Farge and Jean Feunteun and J{\'e}r{\^o}me Galon and Elodie Giroux and Sara Green and Fridolin Gross and Fanny Jaulin and Rob Knight and Ezio Laconi and Nicolas Larmonier and Carlo Maley and Alberto Mantovani and Violaine Moreau and Pierre Nassoy and Elena Rondeau and David Santamaria and Sawai, {Catherine M.} and Andrei Seluanov and Sepich-Poore, {Gregory D.} and Vanja Sisirak and Eric Solary and Sarah Yvonnet and Lucie Laplane",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.",

year = "2023",

doi = "10.1111/brv.12971",

language = "English",

volume = "98",

pages = "1668--1686",

journal = "Biological Reviews",

issn = "1464-7931",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Reuniting philosophy and science to advance cancer research

AU - Pradeu, Thomas

AU - Daignan-Fornier, Bertrand

AU - Ewald, Andrew

AU - Germain, Pierre Luc

AU - Okasha, Samir

AU - Plutynski, Anya

AU - Benzekry, Sébastien

AU - Bertolaso, Marta

AU - Bissell, Mina

AU - Brown, Joel S.

AU - Chin-Yee, Benjamin

AU - Chin-Yee, Ian

AU - Clevers, Hans

AU - Cognet, Laurent

AU - Darrason, Marie

AU - Farge, Emmanuel

AU - Feunteun, Jean

AU - Galon, Jérôme

AU - Giroux, Elodie

AU - Green, Sara

AU - Gross, Fridolin

AU - Jaulin, Fanny

AU - Knight, Rob

AU - Laconi, Ezio

AU - Larmonier, Nicolas

AU - Maley, Carlo

AU - Mantovani, Alberto

AU - Moreau, Violaine

AU - Nassoy, Pierre

AU - Rondeau, Elena

AU - Santamaria, David

AU - Sawai, Catherine M.

AU - Seluanov, Andrei

AU - Sepich-Poore, Gregory D.

AU - Sisirak, Vanja

AU - Solary, Eric

AU - Yvonnet, Sarah

AU - Laplane, Lucie

PY - 2023

Y1 - 2023

N2 - Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

AB - Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

KW - cancer stem cells

KW - clonal evolution

KW - driver mutation

KW - multicellularity

KW - oncoimmunology

KW - philosophy of cancer

KW - tumorigenesis

KW - tumour microenvironment

U2 - 10.1111/brv.12971

DO - 10.1111/brv.12971

M3 - Journal article

C2 - 37157910

AN - SCOPUS:85158094559

VL - 98

SP - 1668

EP - 1686

JO - Biological Reviews

JF - Biological Reviews

SN - 1464-7931

ER -

ID: 347000897